- Title
- Individual patient assessment of methadone-induced QT prolongation with digital holter recording
- Creator
- Calver, Leonie; Dunlop, Adrian J.; Isbister, Geoffrey K.
- Relation
- Journal of Addiction Medicine Vol. 61, Issue 1, p. 92-93
- Publisher Link
- http://dx.doi.org/10.1097/ADM.0b013e31823c4217
- Publisher
- Lippincott Williams & Wilkins
- Resource Type
- journal article
- Date
- 2012
- Description
- A 27-year-old male who had been on methadone therapy for 6 months was investigated with a 12-lead digital holter because of a prolonged QT on a standard 12-lead electrocardiogram (ECG). The patient had 24-hour holter recording on and off methadone therapy and multiple digitized 12-lead ECG data were captured for on-screen measurement of the QT interval. For each 24-hour period QT-HR pairs were plotted on the QT nomogram showing QT prolongation on methadone but not when it was ceased. This provides a highly accurate method for evaluating drug-induced QT prolongation.
- Subject
- methadone; opiod replacement therapy; QT prolongation; torsades des pointes
- Identifier
- http://hdl.handle.net/1959.13/1046013
- Identifier
- uon:14563
- Identifier
- ISSN:1932-0620
- Rights
- This is a non-final version of an article published in final form in Journal of Addiction Medicine Vol. 61, Issue 1, p. 92-93 (2012)
- Language
- eng
- Full Text
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